The Use of a Nonradioactive Digoxigenin Labeled Probe for Detection of Apo(a) Gene Size
نویسندگان
چکیده
247 Abstract: Elevated lipoprotein(a) [Lp(a)] concentrations are associated with premature coronary heart disease and early myocardial infarction. In the general human population the sizes of apolipoprotein [apo(a)] isoforms are inversely associated with lipoprotein(a) levels. Large isoforms are associated with low Lp (a) and small isoforms with high Lp(a) in the plasma. The size of the polymophism is directly correlated with the number of kringle-4 domains in apo(a). It has been shown by quantitative Southern blotting, and more recently by pulsed-field gel electrophoresis, that polymophism is the result of differences in the number of tandem kringle-4 repeats in the apo(a) gene.
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